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lifting
hydrating
smoothing
A limited-edition collagen-revival skincare set featuring our most advanced eye and face formulas powered by proprietary 4-CLGN™ Peptide Complex and clinically-proven to improve the appearance of wrinkles, loss of elasticity, sagging, and dryness for visibly healthier, more youthful-looking skin. A $248 value (saves you $57). Features:
NEW Exo-Plex™ Collagen Renewal Eye Cream (NET 15mL / 0.5 FL OZ): a multi-system eye concentrate powered by bioengineered exosomes to increase firmness by up to 66%* and reduce crepey texture by up to 71%* for total eye rejuvenation.
P46™ Peptide + HA Plumping Facial Serum (NET 30ml/ 1 FL OZ): a 2-in-1 cutting-edge treatment that boosts hydration by up to 2.8x* and increases elasticity by up to 33%* for immediate plumping and long-term visible lifting.
Tested for use on sensitive and post-procedure skin. Fragrance-free, non-comedogenic, gluten-free, cruelty-free, vegan.
*see clinical section for study design

up to 66%
increase in eye-area firmness
up to 71%
decrease in under-eye crepey texture
up to 33%
increase in elasticity
up to 25%
decrease in fine lines & wrinkles
up to 66%
increase in eye-area firmness
up to 71%
decrease in under-eye crepey texture
up to 33%
increase in elasticity
up to 25%
decrease in fine lines & wrinkles
up to 66%
increase in eye-area firmness
up to 71%
decrease in under-eye crepey texture
up to 33%
increase in elasticity
up to 25%
decrease in fine lines & wrinkles
up to 66%
increase in eye-area firmness
up to 71%
decrease in under-eye crepey texture
up to 33%
increase in elasticity
up to 25%
decrease in fine lines & wrinkles
up to 3x increase in skin hydration
Up to:
66% increase in firmness
71% decrease in crepey texture
20% reduction in sagging upper eyelids
33% overall eye rejuvenation
50% increase in smoothness
37% increase in brightness
33% decrease in dark circles
16% improvement in elasticity
25% decrease in static lines + wrinkles
11% decrease in dynamic lines + wrinkles
33% reduction in puffiness
100% said Exo-Plex™ helped visibly smooth fine lines & wrinkles around the eye (v)
100% said Exo-Plex™ visibly brightened (v)
91% said Exo-Plex™ helped strengthen my skin barrier (iv)
90% said Exo-Plex™ helped visibly firm and tighten (v)
95% said Exo-Plex™ is calming and soothing (iv)
100% said Exo-Plex™ is gentle (iv)
100% said Exo-Plex™ is the perfect complement to my procedure (v)
95% said Exo-Plex™ amplified the results of their procedure (v)
95% would recommend using Exo-Plex™ post-procedure (vi)
90% said my eye area looks better than it typically does when i’m due for my next procedure (vi)
86% said Exo-Plex™ helped their skin recover more quickly post-procedure (iv)
85% said Exo-Plex™ extended the results of their procedure (vi)
(i) Based on a 12-week independent clinical study of 34 subjects who used Exo-Plex™ at the immediate time point.
(ii) Based on a 12-week independent clinical study of 34 subjects who used Exo-Plex™ 2x daily at the 12-week time point.
(iii) Based on a 12-week randomized, double-blind, placebo-controlled clinical study of 34 subjects who used Exo-Plex™ and placebo leading moisturizer 2x daily at the 12-week time point.
(iv) Based on a 3 month clinical study of 23 subjects who used Exo-Plex™ 2x daily at the 2-week time point following professional in-office procedure.
(v) Based on a 3 month clinical study of 21 subjects who used Exo-Plex™ 2x daily at the 4-week time point following professional in-office procedure.
(vi) Based on a 3 month clinical study of 21 subjects who used Exo-Plex™ 2x daily at the 12-week time point following professional in-office procedure.
Up to:
42% increase in skin smoothness
25% increase in skin plumpness/volume
55% increase in skin brightness/luminosity
44% improvement in overall healthy appearance
96% would recommend P46™ to a friends (ii)
96% said skin looks and feels softer and smoother (ii)
92% said skin feels soothed (ii)
92% said P46™ deeply hydrates their skin (ii)
96% said skin overall appears more healthy (i)
88% said skin texture looks improved (i)
100% said P46™ helped their skin recover more quickly post-procedure
100% said P46™ improved visible redness in their skin post-procedure
100% said P46™ was calming and soothing on their post-procedure skin
100% said P46™ improved the dryness of their skin post-procedure
100% said P46™ helped improve their skin barrier post-procedure
93% said P46™ made my skin feel stronger and more resilient
93% said P46™ enhanced the results of their procedure
(i) Independent clinical study, 25 subjects who used P46™ 2x daily, measured at the 12-week time point.
(ii) Clinical study, 25 subjects who used P46™ 2x daily, measured at the 1-week time point.
(iii) 4-week clinical study of 14 subjects who used P46™ 2x daily following professional in-office procedure, measured at the 4-week time-point.
(iv) Independent CORNEOMETER® clinical study, 25 subjects who used P46™Serum, measured at the immediate time point.
Key Ingredients
How to use P46™ + Exo-Plex™ when Skin Cycling
LEARN MORE ABOUT SKIN CYCLING
Sustainability
Sustainable Materials
Components use post-industrial recycled (PIR) glass and post-consumer recycled (PCR) plastic. All products are housed in FSC®️-certified cartons and recyclable shippers.
Airless Technology
Airless pumps maximize how much formula you get out of your bottle, plus protect your skincare from oxygen—keeping it potent and effective.
Eco-Friendly Refills
Run out, refill, then reuse our glass bottles. Keep and reuse your top pump, it connects to this refill tube.
Sustainable Materials
Cruelty-Free Formulas
Up to:
27% decrease in skin sagging
25% reduction in visible fine lines & wrinkles
42% increase in skin firmness
25% increase in skin plumpness/volume
55% increase in skin brightness/luminosity
44% improvement in overall healthy appearance
96% would recommend P46™ to a friends (ii)
96% said skin looks and feels softer and smoother (ii)
92% said skin feels soothed (ii)
92% said P46™ deeply hydrates their skin (ii)
96% said skin overall appears more healthy (i)
88% said skin texture looks improved (i)
100% said P46™ helped their skin recover more quickly post-procedure
100% said P46™ improved visible redness in their skin post-procedure
100% said P46™ was calming and soothing on their post-procedure skin
100% said P46™ improved the dryness of their skin post-procedure
100% said P46™ helped improve their skin barrier post-procedure
93% said P46™ made my skin feel stronger and more resilient
93% said P46™ enhanced the results of their procedure
up to 3x increase in skin hydration
Up to:
66% increase in firmness
71% decrease in crepey texture
20% reduction in sagging upper eyelids
33% overall eye rejuvenation
50% increase in smoothness
37% increase in brightness
33% decrease in dark circles
16% improvement in elasticity
25% decrease in static lines + wrinkles
11% decrease in dynamic lines + wrinkles
33% reduction in puffiness
100% said Exo-Plex™ helped visibly smooth fine lines & wrinkles around the eye (v)
100% said Exo-Plex™ visibly brightened (v)
91% said Exo-Plex™ helped strengthen my skin barrier (iv)
90% said Exo-Plex™ helped visibly firm and tighten (v)
95% said Exo-Plex™ is calming and soothing (iv)
100% said Exo-Plex™ is gentle (iv)
100% said Exo-Plex™ is the perfect complement to my procedure (v)
95% said Exo-Plex™ amplified the results of their procedure (v)
95% would recommend using Exo-Plex™ post-procedure (vi)
90% said my eye area looks better than it typically does when i’m due for my next procedure (vi)
86% said Exo-Plex™ helped their skin recover more quickly post-procedure (iv)
85% said Exo-Plex™ extended the results of their procedure (vi)
P46™ SERUM
(i) Independent clinical study, 25 subjects who used P46™ 2x daily, measured at the 12-week time point.
(ii) Clinical study, 25 subjects who used P46™ 2x daily, measured at the 1-week time point.
(iii) 4-week clinical study of 14 subjects who used P46™ 2x daily following professional in-office procedure, measured at the 4-week time-point.
(iv) Independent CORNEOMETER® clinical study, 25 subjects who used P46™Serum, measured at the immediate time point.
EXO-PLEX™ EYE CREAM
(i) Based on a 12-week independent clinical study of 34 subjects who used Exo-Plex™ at the immediate time point.
(ii) Based on a 12-week independent clinical study of 34 subjects who used Exo-Plex™ 2x daily at the 12-week time point.
(iii) Based on a 12-week randomized, double-blind, placebo-controlled clinical study of 34 subjects who used Exo-Plex™ and placebo leading moisturizer 2x daily at the 12-week time point.
(iv) Based on a 3 month clinical study of 23 subjects who used Exo-Plex™ 2x daily at the 2-week timepoint following professional in-office procedure.
(v) Based on a 3 month clinical study of 21 subjects who used Exo-Plex™ 2x daily at the 4-week timepoint following professional in-office procedure.
(vi) Based on a 3 month clinical study of 21 subjects who used Exo-Plex™ 2x daily at the 12-week timepoint following professional in-office procedure.
FULL INGREDIENT LIST: Water/Aqua/Eau, Squalane, Propanediol, Glycerin, Sorbitol, Dicaprylyl Carbonate, Butylene Glycol, C10-18 Triglycerides, Punica Granatum Sterols, Rosa Canina Seed Oil, Vitis Vinifera (Grape) Seed Oil, Glyceryl Stearate SE, Tetrahexyldecyl Ascorbate, Polyglyceryl-3 Rice Branate, PEG-240/HDI Copolymer Bis-Decyltetradeceth-20 Ether, Chlamydomonas Reinhardtii Extract, Tripeptide-1, Palmitoyl Tripeptide-1, Acetyl Dipeptide-1 Cetyl Ester, Palmitoyl Tetrapeptide-7, Beta-Glucan, Acetyl Hexapeptide-8, Sodium Polyglutamate, Sodium Hyaluronate, Astaxanthin, Haematococcus Pluvialis Oil, Caffeine, Coffea Arabica (Coffee) Seed Extract, Panthenol, Betaine, Hippophae Rhamnoides Fruit Oil, Helianthus Annuus (Sunflower) Seed Oil, Tocopherol, Lecithin, Tocopheryl Acetate, Cetearyl Alcohol, Sucrose Stearate, Sodium Lactate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Sorbitan Laurate, Polyglyceryl-4 Caprate, Hydroxyethylcellulose, Pentylene Glycol, Glucose, Polysorbate 20, Potassium Laurate, Dextran, Carbomer, Phenoxyethanol, Ethylhexylglycerin, Sodium Benzoate, Sodium Phytate, Caprylyl Glycol
FORMULATED WITHOUT: fragrance, essential oils, parabens, animal derivatives, formaldehyde-releasers, drying alcohols, phthalates, petrolatum, silicones.
FULL INGREDIENT LIST: Water/Aqua/Eau, Propanediol, Butylene Glycol, Squalane, Glycerin, Capryloyl Glycerin/Sebacic Acid Copolymer, Tripeptide-1, Palmitoyl Tripeptide-1, Acetyl Dipeptide-1 Cetyl Ester, Palmitoyl Tetrapeptide-7, Beta-Glucan, Polyglutamic Acid, Sodium Hyaluronate, Ethylhexyl Olivate, Sodium Lactate, Polyacrylate Crosspolymer-6, Phenoxyethanol, Pentylene Glycol, Ethylhexylglycerin, Sodium Acrylates Copolymer, Sorbitan Laurate, Sodium Phytate, Polyglyceryl-4 Oleate, Citric Acid, Hydroxyethylcellulose, Dextran, Carbomer, Caprylyl Glycol, Coco-Glucoside
FORMULATED WITHOUT: fragrance, essential oils, parabens, animal derivatives, formaldehyde-releasers, drying alcohols, phthalates, petrolatum, silicones.
Use P46™ Serum every morning and night as the first step after cleansing. Directly follow with Exo-Plex™ Eye Cream.
Skin Cycling is a strategic, customizable program, created by Dr. Bowe, for cycling through your evening skincare to maximize results, while minimizing irritation. Skin Cycling takes a streamlined, “smarter, not more” approach to skincare, making your products work harder and better for you. With 3.5 billion TikTok views, the viral program has influenced skincare worldwide.
Below is the Classic Skin Cycling Program, which can be customized by adding more Retinal Nights or Recovery Nights depending on your skin's needs.
Night 1: Exfoliation Night
Dr. Bowe opts for chemical exfoliating products over harsh and gritty scrubs. A chemical exfoliating serum can give your skin an immediate glow, prepping you to get the most out of night 2. Exfoliation Night™ Resurfacing + Brightening Serum is specifically formulated to push your skin outside its comfort zone, driving clinically-proven results on night 1 of your Skin Cycling Program, without harming the delicate skin barrier.
Night 2: Retinoid Night
Retinoids are one of the powerful ingredients to include in your Skin Cycling Program. They work to improve skin by breaking down dead skin cells and generating new skin cells—firming and smoothing the look of skin. Your skin’s sensitivity may influence the strength of the retinoid you choose, as some people can tolerate a retinoid more frequently than others. Retinal is the most powerful retinoid you can get without a prescription. Due to Dr. Bowe's expert formulation of Retinal Night™ Advanced 0.1% Retinal Firming Treatment, it's proven to be highly-potent and stable, yet also clinically-proven to be well-tolerated by skin. This makes Retinal Night™ perfect for leveling up any Skin Cycling Program.
Night 3 + 4: Recovery Nights
Hold off on exfoliating acids and retinoids and give your skin a chance to recover. On Recovery Nights, you want to focus on nourishing your skin microbiome and repairing your skin barrier—think hydration and moisture. Dr. Bowe developed Bowe Glowe™ Microbiome Nourishing Cream for every morning, then each night of your Skin Cycling Program, but especially for Recovery Nights to give your skin the hydration and barrier repair it needs. It has been clinically-proven to help repair the skin barrier in just one hour!*
