P46™

Name: P46™
Brand: Dr. Whitney Bowe Beauty
SKU: P46199
Price: 130.0 USD
Availability: InStock

Peptide + HA Plumping Serum

A 2-in-1 treatment for collagen revival.

$130

$130 · One Time Purchase

$215 · Get the Procedure Enhancement Program

Product variants

lifting

hydrating

clinically-proven

A NEW 2-in-1 peptide + hyaluronic acid serum created by dermatologist Dr. Whitney Bowe to deliver immediate hydration and long-term visible lifting and plumping. Inspired by 6 of the most effective in-office collagen-rejuvenating treatments and powered by proprietary 4-CLGN™ Complex and HA Amplification Technology to visibly restore skin’s youthful resilience and bounce.

Floods skin with up to 2.8x the hydration*
Increases skin elasticity by up to 33%* and reduces skin sagging by up to 27%*
Improves skin firmness, smoothing texture and visibly reducing wrinkles
Boosts luminosity and helps reduce visible redness
Amplifies in-office treatments—soothing skin, expediting recovery, and enhancing results
"Coaches" skin to look and act more youthful with proprietary 4-CLGN™ Complex (four signaling and neurotransmitter-inhibiting peptides + beta-glucan) and HA-Amplification Technology (hyaluronic acid + polyglutamic acid)
Fragrance-free, non-comedogenic, gluten-free, cruelty-free, vegan, refillable, suitable for even the most sensitive skin

Ideal for those experiencing visible signs of aging—wrinkles, volume loss, crepey texture, dryness, dullness, or sensitivity—as well as menopausal skin or skin recovering from in-office procedures.

*see clinical section for study design

Clinically-Proven Results

When using P46™

Before

After

up to 33%

increase in skin elasticity (i)

up to 27%

decrease in skin sagging (i)

up to 2.8x

increase in skin hydration after one application (iv)

up to 25%

decrease in fine lines & wrinkles (i)

When using P46™

Before

After

up to 33%

increase in elasticity

up to 27%

decrease in sagging

up to 2.8x

increase in hydration after one application

up to 25%

decrease in wrinkles

When using P46™

Before

After

up to 33%

increase in elasticity

up to 27%

decrease in sagging

up to 2.8x

increase in hydration after one application

up to 25%

decrease in wrinkles

When using P46™

Before

After

up to 33%

increase in elasticity

up to 27%

decrease in sagging

up to 2.8x

increase in hydration after one application

up to 25%

decrease in wrinkles

When using P46™

Before

After

up to 33%

increase in elasticity

up to 27%

decrease in sagging

up to 2.8x

increase in hydration after one application

up to 25%

decrease in wrinkles

up to 33%

increase in elasticity (i)

up to 27%

decrease in sagging (i)

up to 2.8x

increase in hydration after one application (i)

up to 25%

decrease in wrinkles (i)

SEE ALL RESULTS

Key Ingredients

Peptides Hyaluronic Acid Beta-Glucan Polyglutamic Acid SEE ALL INGREDIENTS

How to Use
P46™

Apply 3-4 pumps onto the face, neck, and chest each morning and night after cleansing. Suitable to use after in-office treatments on even the most sensitive, post-procedure skin.

How to use P46™ Serum when Skin Cycling

LEARN MORE ABOUT SKIN CYCLING

Sustainability

Made with eco-friendly materials and airless technology

Sustainable Materials

Cruelty-Free Formulas

Clinical Results

MORE OBJECTIVE CLINICALLY-PROVEN RESULTS (i):

Up to:

42% increase in skin smoothness

25% increase in skin plumpness/volume

55% increase in skin brightness/luminosity

44% improvement in overall healthy appearance

SUBJECTIVE CLINICALLY-PROVEN RESULTS:

96% would recommend P46™ to a friends (ii)

96% said skin looks and feels softer and smoother (ii)

92% said skin feels soothed (ii)

92% said P46™ deeply hydrates their skin (ii)

96% said skin overall appears more healthy (i)

88% said skin texture looks improved (i)

POST PROCEDURE CLINICALLY-PROVEN RESULTS (iii):

100% said P46™ helped their skin recover more quickly post-procedure

100% said P46™ improved visible redness in their skin post-procedure

100% said P46™ was calming and soothing on their post-procedure skin

100% said P46™ improved the dryness of their skin post-procedure

100% said P46™ helped improve their skin barrier post-procedure

93% said P46™ made my skin feel stronger and more resilient

93% said P46™ enhanced the results of their procedure

(i) Independent clinical study, 25 subjects who used P46™ 2x daily, measured at the 12-week time point.

(ii) Clinical study, 25 subjects who used P46™ 2x daily, measured at the 1-week time point.

(iii) 4-week clinical study of 14 subjects who used P46™ 2x daily following professional in-office procedure, measured at the 4-week time-point.

(iv) Independent CORNEOMETER® clinical study, 25 subjects who used P46™Serum, measured at the immediate time point.

Key Ingredients

4x Peptides

Beta-Glucan

Hyaluronic Acid

Polyglutamic Acid

Water/Aqua/Eau, Propanediol, Butylene Glycol, Squalane, Glycerin, Capryloyl Glycerin/Sebacic Acid Copolymer, Tripeptide-1, Palmitoyl Tripeptide-1, Acetyl Dipeptide-1 Cetyl Ester, Palmitoyl Tetrapeptide-7, Beta-Glucan, Polyglutamic Acid, Sodium Hyaluronate, Ethylhexyl Olivate, Sodium Lactate, Polyacrylate Crosspolymer-6, Phenoxyethanol, Pentylene Glycol, Ethylhexylglycerin, Sodium Acrylates Copolymer, Sorbitan Laurate, Sodium Phytate, Polyglyceryl-4 Oleate, Citric Acid, Hydroxyethylcellulose, Dextran, Carbomer, Caprylyl Glycol, Coco-Glucoside

Skin Cycling

Use P46™ Serum every morning and night as the first step after cleansing.

Skin Cycling is a strategic, customizable program, created by Dr. Bowe, for cycling through your evening skincare to maximize results, while minimizing irritation. Skin Cycling takes a streamlined, “smarter, not more” approach to skincare, making your products work harder and better for you. With 3.5 billion TikTok views, the viral program has influenced skincare worldwide.

Below is the Classic Skin Cycling Program, which can be customized by adding more Retinal Nights or Recovery Nights depending on your skin's needs.

Night 1: Exfoliation Night

Dr. Bowe opts for chemical exfoliating products over harsh and gritty scrubs. A chemical exfoliating serum can give your skin an immediate glow, prepping you to get the most out of night 2. Exfoliation Night™ Resurfacing + Brightening Serum is specifically formulated to push your skin outside its comfort zone, driving clinically-proven results on night 1 of your Skin Cycling Program, without harming the delicate skin barrier.

Night 2: Retinoid Night

Retinoids are one of the powerful ingredients to include in your Skin Cycling Program. They work to improve skin by breaking down dead skin cells and generating new skin cells—firming and smoothing the look of skin. Your skin’s sensitivity may influence the strength of the retinoid you choose, as some people can tolerate a retinoid more frequently than others. Retinal is the most powerful retinoid you can get without a prescription. Due to Dr. Bowe's expert formulation of Retinal Night™ Advanced 0.1% Retinal Firming Treatment, it's proven to be highly-potent and stable, yet also clinically-proven to be well-tolerated by skin. This makes Retinal Night™ perfect for leveling up any Skin Cycling Program.

Night 3 + 4: Recovery Nights

Hold off on exfoliating acids and retinoids and give your skin a chance to recover. On Recovery Nights, you want to focus on nourishing your skin microbiome and repairing your skin barrier—think hydration and moisture. Dr. Bowe developed Bowe Glowe™ Microbiome Nourishing Cream for every morning, then each night of your Skin Cycling Program, but especially for Recovery Nights to give your skin the hydration and barrier repair it needs. It has been clinically-proven to help repair the skin barrier in just one hour!*

Our newest product is dropping soon

P46™

Clinically-Proven Results

When using P46™

When using P46™

When using P46™

When using P46™

When using P46™

Key Ingredients

How to Use P46™

How to use P46™ Serum when Skin Cycling

Sustainability

Made with eco-friendly materials and airless technology

Clinical Results

MORE OBJECTIVE CLINICALLY-PROVEN RESULTS (i):

SUBJECTIVE CLINICALLY-PROVEN RESULTS:

POST PROCEDURE CLINICALLY-PROVEN RESULTS (iii):

Key Ingredients

4x Peptides

Beta-Glucan

Hyaluronic Acid

Polyglutamic Acid

Skin Cycling

How to Use
P46™